Dyadic, VTT Developing Efficient Production Method for COVID-19 Vaccines

By Printed Electronics Now staff | 09.25.20

Advances have been made to develop a new production platform in the industrialized C1 host cell.

Over the last three years, Dyadic and VTT have developed a more efficient and lower cost alternative to produce therapeutic proteins, vaccines and valuable metabolites. 
The method is based on exploiting the Thermothelomyces heterothallica C1 fungal strain. 
The partners are now developing a new production method for a SARS-CoV-2 coronavirus vaccine. 
Currently, the BioPharmaceutical industry is producing therapeutic proteins mainly in the CHO (Chinese hamster ovary) cell system with the current production processes both time consuming and expensive. 
In the Dyadic-VTT collaboration, rapid progress and significant advances have been made to develop a new production platform in the industrialized C1 host cell. 
The C1 gene expression platform provides the possibility to bring affordable medicines to patients sooner and at a lower cost.
”We are at the right time in history to disrupt the biological production of healthcare for vaccine and drugs and it couldn’t have come at a better time because COVID-19 came. We are doing our best to work with as many players around the globe to make sure we can help to eradicate this horrific disease and prolong life and reduce pain and suffering in the process." Dyadic CEO Mark A. Emalfarb said. 
Dyadic's industrially proven filamentous fungal strain of Thermothelomyces heterothallica, nicknamed C1 is known as an extremely robust and efficient protein production organism. 
In addition to being able to produce high levels of enzymes and other proteins, C1 produces glycan structures similar to the human glycan forms making the glycoengineering work quicker and easier.